Parkin Pathway Activation Mitigates Glioma Cell Proliferation and Predicts Patient Survival
نویسندگان
چکیده
منابع مشابه
Parkin pathway activation mitigates glioma cell proliferation and predicts patient survival.
Mutations in the parkin gene, which encodes a ubiquitin ligase, are a major genetic cause of parkinsonism. Interestingly, parkin also plays a role in cancer as a putative tumor suppressor, and the gene is frequently targeted by deletion and inactivation in human malignant tumors. Here, we investigated a potential tumor suppressor role for parkin in gliomas. We found that parkin expression was d...
متن کاملMolecular and Cellular Pathobiology Parkin PathwayActivationMitigatesGliomaCell Proliferation and Predicts Patient Survival
Mutations in the parkin gene, which encodes a ubiquitin ligase, are a major genetic cause of parkinsonism. Interestingly, parkin also plays a role in cancer as a putative tumor suppressor, and the gene is frequently targeted by deletion and inactivation in human malignant tumors. Here, we investigated a potential tumor suppressor role for parkin in gliomas. We found that parkin expression was d...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2012
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-11-3060